2P093 Heme binding region of Bach2 as intrinsically disordered protein(02. Heme proteins,Poster)
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چکیده
منابع مشابه
Ligand Binding to Heme Proteins
The 02, CO, and alkyl isocyanide-binding properties of a variety of vertebrate and invertebrate heme proteins have been compared in detail to those of protoheme mOn0-3-( 1-imidazoy1)-propylamide monomethyl ester in aqueous suspensions of soap micelles. The proteins examined include: cytochrome P-450,,, from Pseudomonasputida, beef heart cytochrome c oxidase, yeast cytochrome c peroxidase, a and...
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Background and objectives: There are several methods to assess the in vitro capability of heme inhibitory activity of antimalarial compounds; most of them require some specific equipment or toxic substances and sometimes the needed materials are not accessible. Regarding the necessity and importance of optimizing and standardizing experimental conditions, the present s...
متن کاملHeme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2.
Heme binds to proteins to modulate their function, thereby functioning as a signaling molecule in a variety of biologic events. We found that heme bound to Bach2, a transcription factor essential for humoral immunity, including antibody class switch. Heme inhibited the DNA binding activity of Bach2 in vitro and reduced its half-life in B cells. When added to B-cell primary cultures, heme enhanc...
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Neudesin is a secreted protein with neurotrophic activity in neurons and undifferentiated neural cells. We report here that neudesin is an extracellular heme-binding protein and that its neurotrophic activity is dependent on the binding of heme to its cytochrome b(5)-like heme/steroid-binding domain. At first, we found that at least a portion of the purified recombinant neudesin appeared to bin...
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The rates of carbon monoxide recombination to six different kinds of chemically modified heme with various substituents at positions 2 and 4 have been studied in the proteinfree state (free heme) by the laser flash photolysis method in a mixture of ethylene glycol and 0.02 N NaOH (80:20, V/V) (80% ethylene glycol). The carbon monoxide combination rate constants to the various free hemes obtaine...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2013
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.53.s174_3